Inflammation, Endothelial Dysfunction, and Thromboembolism

Inflammation, Endothelial Dysfunction, and Thromboembolism.

Inflammatory mechanisms are intimately tied up with direct defense against infection, immunity, and healing. In order for processes to proceed at affected sites within tissues, capillary walls have to be able to modify their permeability to soluble mediators, particles, and cells. These systems are in a delicate balance, which can be easily disrupted, giving rise to exacerbating diseases or dys...

Endothelial Dysfunction and Inflammation

Endothelial dysfunction and inflammation in asymptomatic proteinuria.

BACKGROUND Proteinuria is associated with vascular risk and a systemic increase in vascular permeability. Endothelial dysfunction occurs early in atherosclerosis and modulates vascular permeability. Vascular risk and chronic inflammation are associated. This study investigates whether the increased vascular permeability in proteinuria reflects systemic endothelial dysfunction and chronic inflam...

Adipose tissue, inflammation and endothelial dysfunction.

During the last decade, white adipose tissue was recognized to be an active endocrine organ and a source of many proinflammatory cytokines, chemokines, growth factors and complement proteins. Many of these adipokines seem to play an important role in the pathogenesis of obesity-related diseases including accelerated atherosclerosis, arterial hypertension and some glomerulopathies. As endothelia...

Endothelial dysfunction in patients with spontaneous venous thromboembolism.

BACKGROUND AND OBJECTIVES A high incidence of atherosclerotic lesions and cardiovascular events has been reported in patients with spontaneous venous thromboembolism. Endothelial dysfunction is an early marker of atherosclerosis and has predictive value for ischemic events. We have evaluated endothelial function in patients with a history of spontaneous venous thromboembolism. DESIGN AND METH...